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The drug does not dissolve readily. - Enzymes in the intestine may metabolize some of the drug before it is absorbed. - The liver metabolizes some of the drug on its first pass through the liver on the way to the systemic circulation.

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1. The drug does not dissolve readily. - Enzymes in the intestine may metabolize some of the drug before it is absorbed. - The liver metabolizes some of the drug on its first pass through the liver on the way to the systemic circulation.





 
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