Which genetic disorder is associated with dysfunction of gap junction?

The extracellular matrix (ECM) provides structural support to cells and tissues. It also generates cell signals that affect cell proliferation, differentiation, migration, and adhesion.  ECM-cell interactions are mediated by cell surface receptors, either directly or indirectly with cooperative molecules. The ECM is also constantly remodeling, which influences cell-signaling pathways.  ECM-cell interactions play a crucial role in: Embryonic development Differentiation Tissue remodeling Diseases like fibrosis and cancer  Dysregulated signaling between the ECM and cells can lead to... Show more

The extracellular matrix (ECM) provides structural support to cells and tissues. It also generates cell signals that affect cell proliferation, differentiation, migration, and adhesion. 
ECM-cell interactions are mediated by cell surface receptors, either directly or indirectly with cooperative molecules. The ECM is also constantly remodeling, which influences cell-signaling pathways. 

ECM-cell interactions play a crucial role in:
Embryonic development
Differentiation
Tissue remodeling
Diseases like fibrosis and cancer 
Dysregulated signaling between the ECM and cells can lead to different diseases. 
 

Topics include: Cells Interaction - Integrins, Cells Interaction, Immunoglobulin Superfamily, Adherens Junctions, Tight Junctions, Gap Junctions, & Cell Walls.

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