Biopharmaceutics
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Biopharmaceutics
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25 Questions

1. The rate of desorption is proportional to the
2. Nucleation process is involved in
3. Which one of the following process is responsible for higher half-life of drug?
4. Zolmitryptan is given i.v to the patient in dose of 1.2 mg/ kg (AUC = 450 μg.hour/I).Same drug was given as oral SR tablet in dose 8.0 mg/kg (AUC = 1040 μg.hour/I). What is the absolute bioavailability of SR tablet?
5. Which one of the following physicochemical properties is more important for passive diffusion of drugs from the gastrointestinal tract?
6. The reaction rate constant (k) is 2.0 × 10'3 min'1 for aspirin hydrolysis in 0.1 N hydrochloric acid at 1 mg/ml concentration. Under same conditions, if the product contains aspirin 4 mg/ml of the initial concentration, the k value in minute'1 will be
7. In Michaelis'Menten equation when Km = C
8. Half life of drug may be useful to determine
9. Which of the following mechanisms of drug absorption is saturable type?
10. Unit of apparent volume of distribution is
11. Which category of drug is evaluated for dissolution?
12. Higher absorption of drug through small intestine is due to
13. According to the pH partition theory, a weakly acidic drug will be absorbed more likely from the stomach, because the drug exists primarily in the:
14. Ideal solid content of a freeze dried product should be
15. Innulin is used as a marker for measurement of
16. The loading dose (DL) of a drug is usually based on the
17. How much solvent is required to dissolve a sparingly soluble salt?
18. The half life of a first-order reaction is 4 years. What is its shelf life (in years)?
19. Surfactant increases the bioavailability of a drug by
20. Flip-flop phenomenon occurs when
21. Drug X has a molecular weight of 750 daltons. From which of the following route will it get excreted?
22. Following is not true for pKa of a drug
23. Phase II reactions of a drug biotransformation
24. Sigma'Minus method is used to determine the ________
25. The half-life for first-order photolysis of cefotaxime solution containing 150 mg drug is 50 min. If 1ml aliquot after 90 min of exposure to light was found to contain 0.43 mg of cefotaxime, what was the original volume the solution?

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