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USMLE Musculoskeletal System Question Bank

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Your musculoskeletal system includes your bones, cartilage, ligaments, tendons and connective tissues. Your skeleton provides a framework for your muscles and other soft tissues. Together, they support your body's weight, maintain your posture and help you move.

USMLE Musculoskeletal System Question Bank

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25 Questions

1. If someone with down syndrome presents with: -increased tone -upgoing Babinski -Hyperreflexia 1. What investigation should you consider. 2. What pathology are you suspecting?

1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Radial nerve 2. Extensor pollicis longus/brevis1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A

2. What organisms are most common for necrotizing fascitis? 2. What toxins do they make that cause symptoms?

1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.1. Radial nerve 2. Extensor pollicis longus/brevis1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A

3. Microscopy of aspirate from a gout effected joint will show what? 2. What are they made of? 3. What do you treat acute attacks with?

1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A1. Radial nerve 2. Extensor pollicis longus/brevis1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.

4. Which nerve is responsible for thumb extension? 2. What muscles involved?

5. What is cleidocranial dysostosis?

1. Autosomal dominant disorder affecting intromembraneous ossification. Presents with variably abnormal skull, maxilla, madnible, pelvis, clavicles.1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.

6. What condition is associated with heterotopic ossification? 2. What is it? 3. What does it usually occur as a result of?

1. Myositis ossificans 2. Bone growth in non bone tissue. 3. Result of trauma to skeletal muscle with excess etravasation of RBC and metaplastic bone formation.1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.

7. What nerve is commonly compressed in pregnant women? 2. What muscles are innervated by this nerve? 3. What is the cutaneous innervation of this nerve.

1. Mediam nerve = carpal tunnel syndrome. 2. Abductor pollicis brevis Flexor pollicis brevis Opponens pollicis 3. Ventral lateral aspects of palm from the lateral half or the fourth digit to the thumb and ventral and dorsal fingertips of the first three lateral digits and the lateral half of the fourth fingertip.1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.

8. What is cori disease? 2. What causes it?

1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.1. Type 3 glycogen storage disease. 2. Glycogen debranching ezyme deficiency1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.

9. What are the two most common muscular dystrophies? 2. What protein is affected? 3. Mutation type seen in DMD vs BMD? 4. What sign is seen in MD? 5. What is most common cause of death in MD?

1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Duchenne and Becker. 2. Dystrophin 3. DMD = frame shit and BMD = in frame 4. Gowers sign 5. Dilated cardiomyopathy and respiratory failure1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.

10. A women diagnosed with rheumatoid arthritis begins treatment but after several months blood work shows that she is: -Anemic -Leukopenic -Thrombocytopenic -Slight increase in mean corpuscular volume 1. Addition of what to her treatment would most likely have prevented these symptoms? 2. What drug treatment is she being given? 3. What are adversce side effects of this drug?

1. Folic acid 2. Methotrexate 3. Stomatitis, GIT, pancytopenia1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.

11. Which nerve only comes off the lateral cord of the brachial plexus?

12. What is vertebrobasilar insufficiency? 2. What are two common causes of this? 3. What are the general features of this condition?

1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Decreased blood flow to brian stem. 2. Athersclerosis and cervical spondylosis. 3. Presents as a brain stem injury: -Upper/lower limb weakenss -Ataxia -Opthalmoplegia -Vertigo1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A

13. What is cyclobenzaprine?

Muscle relaxant used to relieve acute temporary muscle spasm. not used in surgery.1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.

14. Injury to the humerus that results in difficulty abducting the arm with some sensory loss over skin of lateral shoulder is due to: 1. Injury to what nerve? 2. Where is the fracture most likely to have occured? 3. What is the quadrangular space?

1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.1. Axillary nerve = posterior cord of brachial plexus. 2. Fracture of the surgical neck of the humerus. 3. Space which auxillary nerve passes through to supply deltoid and teres minor muscle. Formed by: -Teres minor -Teres major -Surgical neck of humerus -Long head of triceps

15. If someone suffers a slash on their ventral forearm and the only damage they suffer is to the nerve that is emmediatly lateral to the flexor digitorum superficialis tendon which action will they no longer be able to perform?

Actions of the median nerve: -Flexion of 2nd and 3rd digits -Abduction of pollics -Pollicis opposition -Pollicis flexion -Wrist flextion -Pronation -Loss of sensation1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.

16. What sort of hypersensitivity is myasthenia gravis? 2. What is causing the weakness in MG? 3. What are most common muscles affected?

1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.1. Type 2 2. Autoantibodies bind to acetocholine receptors in motor neuron plate which preven Ach binding 3. Occular and bulbar1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.

17. What is klumpke paralysis? 2. Where does lesion occur? 3. What are features of it? 4. Common causes of it?

1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.1. Brachial plexus injury 2. Lower part/trunk of brachia plexus (C8-T10) 3. Paralysis or weakness of intrinsic hand muscles and numbness on inner aspect of hand. Partial photsis nad miosis of pupil. 4. Breech delivery or over extention of arm.1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A

18. What collagen type is affected in ALport and Goodpastures syndrome?

Type 4 c olalgen1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A

19. A man falls on his elbow. he now has weakness in his hand. Physical exam shows bruising, swelling and pain in the distal humerous and elbow. Neurologic examination shows weakness with thumb adduction and sensory loss on median palm. He has clawing of fourth and fifth digits. 1. Which nerve is likely implicated? 2. Which cord of the brachial plexus does this nerve come off of?

1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Ulnar nerve 2. Medial cord.1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.

20. Alpha fetoprotien is associated with what malignacies?

1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A-Yolk sac tumors -Hepatocellular carcinoma

21. What muscles does the median nerve innervate?

1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A'Forearm = Flexion of forearm Superficial group: -Palmaris Longus -Pronator Teres -Flexor Carpi Radialis Intermediate group -Flexor digitorum superficialis Deep group -Flexor digitorum profundus (lateral half) -Flexor pollicis longus -Pronator quadratus Hand ''LOAF'' -Lumbrical 1/2 -Opponens Pollicis -Abudctor pollicis brevis -Flexor Pollicis brevis'1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.

22. A man hits his hit on ground. Exam shows marked tenderness of palm near fifth digit. Flexion of fifth digit against resistance elicits pain at the same site. No loss of sensation. 1. What is the likely underlying cause of finding? 2. What nerve is near this region?

1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A1. Hook of hamate fracture. 2. Ulnar nerve crosses wrist lateral hook of hamate. But lack of sensory deficits means it is not involved.

23. Which collegen type is affected in osteogenesis imperfecta?

24. What are some associated symptoms of Pagets disease?

1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A-Frontal bossing = increased hat/show size -Hearing loss = auditory foramen narrowing. -High out put cardiac fialure from arterio venous shunts in moasic bone -Osteosarcoma1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.

25. Which muscles do abduction and adduction of the digits? 2. Which nerve innervates them?

1. Interosseous muscles. 2. Ulnar nerve1. Negatively birefringent needle shaped crystal. 2. Monosodium urate 3. Colchicine or indomethacin. Can also add allopurinol.1. Strep pyogenes and clostridium perfringins. 2. Clostridium perfringins = alpha toxin Strep pyogenes = Exotoxin A1. Imaging of cervical spine 2. Suspecting atlantoaxial instability/displacemetn resulting in compression of the spinal cord. People with DS are at increased risk for atlantoaxial instability.

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25 Questions

❤ If you liked Fatskills, consider supporting us by checking out The Life Manuals You Never Got.

About | Explore | User Guide | Topics | Subjects | Doubt Solver | Career Aptitude Test | Answers | Free Tools | What Should We Know? Privacy | Terms |

Without work one finishes nothing. - Ralph Waldo Emerson© 2026 Fatskills.com

All trademarks, logos and brand names are the property of their respective owners. All company, product and service names used in this website are for identification purposes only. Use of these names, trademarks and brands does not imply endorsement.

About | Explore | User Guide | Topics | Subjects | Doubt Solver | Career Aptitude Test | Answers | Free Tools | What Should We Know?
Privacy | Terms |

Without work one finishes nothing. - Ralph Waldo Emerson
© 2026 Fatskills.com