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USMLE Brs Pathology Vocab
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USMLE Brs Pathology Vocab
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25 Questions

1. Iron deficient anemia associated with upper::esophageal web

2. Aggressive B- cell lymphoma - EBV - starry sky appearance - c myc

3. Tumor suppressor mutated in breast and ovary

4. Aka osteitis deformans - increased osteoclastic and osteoblastic activity

5. Mesangial matrix material acculmulations seen in nodular glomerulosclerosis seen in diabetic nephropathy

6. Defective cilia - sinusitis - bronchiectasis - situs inversus - sometimes hearing loss and male sterility

7. Seen in hyperacute rejection - = acute inflammation - fibrinoid necrosis of small vessels - and extensive thrombosis

8. Deficient fibrillin (constituent of microfibrils) - arachnodactyly - ectopia lentis - aortic aneurysm - mitral valve prolapsed

9. Scheinker syndrome :: prion dx - fatal familial insomnia

10. Deficient a1 -4 glucosidase - accumulation of glycogen in liver - heart - skeletal muscle - cardiomegaly - muscle hypotonia - spelnomegaly - intractable hypoglycemia - death from cardiorespiratory failure before age 3

11. Tennis racket shaped cytoplasmic inclusion seen in langerhans cells (so also seen in langerhan cell histiocytosis)

12. Autosomal recessive - conj hyperbilirubinemia - defect in bili transport - black color to liver

13. Deficient debranching enzyme amylo -1 -6- glucosidase - glycogen in liver - heart - skeletal muscle - stunted growth - hepatomegaly - hypoglycemia

14. At least 2 X and one Y - hypogonadism - tall - gynecomastia - low testosterone - high pituitary gonadotropins - infertility -

15. Renal tubular dysfunction - impaired reabsorption of glucose - amino acids - phosphate - and bicarb thus glycosuria - hyperphosphaturia - hypophosphatemia - aminoaciduria - systemic acidosis

16. Hemihypertrophy - macroglossia - organomegaly - neonatal hypoglycemia - various embryonal tumors - deleted WT 2 gene

17. = MEN2a

18. Area of focal interstitial myocardial inflammation characterized by fragmented collagen and fibrinoid material - by large cells (Anitschkow myocytes) and occasional multinucleated giant cells (Aschoff cells)

19. Aspirin toxicity seen in kids after acute febrile viral dx - microvesicular fatty change in liver and encephalopathy

20. Diffuse nodular diabetic glomerulosclerosis

21. Also seen in urine of MM - stacks of RBCs - will have high ESR

22. Mutation here causes pseudohypoparathyroidism

23. Acute promyelocytic leukemia PML gene on 15 and RARa on 17

24. Oncogenes that code for p21 proteins which are membrane signalers

25. Aka subcortical leukoencephalopathy - assoc with HTN - multiple lacunar infarcts and progressive demyelination in subcortical area