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Cell Biology Practice Test: DNA Replication & Repair
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Avg score: 63% • Most missed: “A mismatched base pair can cause ________________ in the double helix.”
DNA replication and repair are essential processes that ensure the correct genetic material is passed on. DNA replication ensures that each daughter cell receives an equal amount of DNA. DNA replication is also necessary for the growth, repair, and regeneration of tissues in living organisms.  DNA replication involves the following steps: Replication fork formation: The double-stranded DNA molecule is "unzipped" into two single strands. Primer binding: The leading strand is the simplest to replicate. Elongation: DNA polymerase adds DNA nucleotides to the 3' end of the... Show more
Cell Biology Practice Test: DNA Replication & Repair
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25 Questions

1. Which if the following polymerases have an unusually spacious active site?
2. Which form of Xeroderma pigmentosum is observed in patients who cannot synthesize functional polymerase Η?
3. Which enzyme removes the positive supercoils generated when the replication fork?
4. Which repair system operates to remove the altered bases generated by reactive chemicals present in the diet?
5. Which of the following enzyme is responsible for initiating DNA replication?
6. The bacterial oriC is the __________________
7. Movement of the replication fork generates ________________ in the unreplicated portion of DNA.
8. Xeroderma pigmentosum is caused by ______________________
9. A mismatched base pair can cause ________________ in the double helix.
10. Which repair system operates to repair DNA strands that are actively transcribed?
11. How many types of skin cancers can develop by overexposure to ultraviolet rays?
12. Translesion synthesis polymerases lack processivity.
13. Which of the following does not introduce double-strand breaks in the DNA?
14. Who made the discovery that one DNA strand is synthesized discontinuously in fragments?
15. The lagging strand is synthesized discontinuously.
16. The NHEJ pathway is used to rectify __________________ in the DNA.
17. When was DNA polymerase III discovered as the major enzyme behind DNA replication in bacteria?
18. Which enzyme joins the Okazaki fragments into a continuous strand?
19. How many types of replication models were considered before the semiconservative nature of DNA replication was confirmed?
20. How many pathways of nucleotide excision repair exist?
21. Which isotopes were used by the researchers who first confirmed the semiconservative nature of DNA replication?
22. How many copies (approximately) of DNA polymerase III are present in a typical bacterial cell?
23. Temperature-sensitive mutants can not replicate their chromosomes at non-permissive temperatures.
24. Replicative polymerase Η belongs to a family of polymerases involved in ________________
25. Mutations in the DNA may be passed to the next generation.

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