GPAT Paper 2011
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GPAT Paper 2011
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25 Questions

1. What will be the dose required to maintain therapeutic concentration of 20 microgram/ml for 24 h of a drug exhibiting total clearance of 2 L/h?
2. Inhibition/induction of which of the following Cytochrome P450 enzyme system is most likely to be involved in important drug-drug interactions?
3. Non-linear pharmacokinetics can be expected due to (P) Enzyme induction (Q) Active secretion Choose the correct answer.
4. Each of the following option lists a phytoconstituent, its phytochemical grouping, pharmacological activity and corresponding semisynthetic analogue. Find a mismatching option.
5. Five-membered heteroaromatic compounds show a much higher rate of electrophilic aromatic substitution reactions than the six-membered ones. This is due to which one of the following reasons?
6. Patients taking isosorbide mononitrate or nitroglycerine should be advised not to take sildenafil. This drug-drug interaction causes which of the following actions?
7. Blood level monitoring of HbAlc is important in which of the given diseased states?
8. What is the heat of vaporization of water at 1000?
9. What is the wavenumber equivalent of 400 nm wavelength?
10. Define Plasmapheresis. Choose the correct answer.
11. Which statement is false for Association Colloids?
12. A tooth paste contains stannous fluoride and calcium pyrophosphate along with other formulation constituents. Choose the correct statement out of the following.
13. In context of complexometry (complexometric titrations), the two terms labile and inert complexes, are used frequently. Choose the correct statement about them.
14. Which of the following statements is true for angiotensin- II.
15. Which microbe is used for validation of sterilization by filtration process?
16. Which one of the following is a beta lactamase inhibitor?
17. Which statement is not true for steam distillation?
18. Which one of the following does not afford a macromolecular inclusion compound?
19. The degree of flocculation of a suspension is 1.5 and the sedimentation volume is 0.75. What will be the ultimate volume of deflocculated suspension?
20. A drug whose solubility is 1 g/L in water, when given orally at a dose of 500 mg is absorbed upto 95% of the administered dose. The drug belongs to which class according to the BCS classification?
21. Name the compound used for standardization of Karl-Fisher reagent in aquametry.
22. Which of the following skeletal muscle relaxants acts directly on the contractile mechanism of the muscle fibers?
23. The following options carry the name of the plant, part used and its family. Find a wrong combination.
24. Aprotic polar solvents increase the rate of SN2 reactions manifold. Enhancement in the rate of such reactions is due to which one of the following effects?
25. Indicators used in complexometric titrations are chelating agents. Choose the correct statement about them.

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