Septic-arthritis: What is the most common organism for: neonates? Under 16s? 16-40? Over 40?

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1. Septic-arthritis: What is the most common organism for: neonates? Under 16s? 16-40? Over 40?

A systemic illness characterized by the presence of fever, arthralgia +/-pneumonitis and conjunctivitis, and mucocutaenous erythema multiforme like lesions (target lesions - circular lesions with central blister). Thought to be related to toxic epidermal necrosis since they have a similar inflammatory inflitrate char'd by a cell-poor infiltrate of mac and dendrocytes with strong tnf-alpha immunoreactivity. Distinct from the high density of cell infiltrate t-lymphocyte rich infiltrate found in erythema multiforme.
Activated t cells infiltrate orbital contents and stimulate fibroblasts leading to: enlargement of extraocular muscles cellular infiltration of interstitial tissues proliferation of orbital fat and connective tissue (leading to fibrosis of involved muscle and tethering)
Neonates: s aureus, group b strep, gram negative bacilli under 16s: s aureus, s pyogenes 16-40: n gonorrhoea, s aureus, s pyogenes over 40: s aureus
Lymphadenopathy = enlargement of lymph nodes How large? Soft, flat submandibular ln of less than 1cm are often palpable in healthy children and young adults, healthy adults may have palpable inguinal nodes of up to 2cm

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Septic-arthritis: What is the most common organism for: neonates? Under 16s? 16-40? Over 40?

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