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A 35 yo man is brought to ED with fever, chills and weight loss and night sweats. Temp is 101.3 other vitals are normal. He has anterior cervical lymphadenoapthy, marked apllor. Microscopic exam of biopsy from a lymph node shows large, binucleated cells with prominent nucleoli with an eosinophilic cytoplasm, Combination therapy is started. Patient returns 7 days later with severe bladder spasms, irritative voiding and gross hematuria. Physical exam shows marked suprapubic pain. Vitals are stable. 1. What is the MOA of the most likely drug causing these symptoms? 2. What are the large, binucleated cells with prominent nucleoli with eosinophilic cytoplasm.

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The General Principles section of the USMLE covers these topics:
Biochemistry
Genetics
Microbiology
Pathology
Pharmacology


1. A 35 yo man is brought to ED with fever, chills and weight loss and night sweats. Temp is 101.3 other vitals are normal. He has anterior cervical lymphadenoapthy, marked apllor. Microscopic exam of biopsy from a lymph node shows large, binucleated cells with prominent nucleoli with an eosinophilic cytoplasm, Combination therapy is started. Patient returns 7 days later with severe bladder spasms, irritative voiding and gross hematuria. Physical exam shows marked suprapubic pain. Vitals are stable. 1. What is the MOA of the most likely drug causing these symptoms? 2. What are the large, binucleated cells with prominent nucleoli with eosinophilic cytoplasm.





 
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