In relation to inulin what happens to the concentration of the following in the tubule: 1. Bicarbonate 2. Glucose 3. Sodium 4. Urea 5. Creatinine

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Use the mnemonic, A WET BED: A) maintenance of ACID-base balance; W) maintenance of WATER balance; E) balance of ELECTROLYTES; T) removal of TOXINS; B) control of BLOOD pressure; E) production of ERYTHROPOIETIN; and D) metabolism of vitamin D.

1. In relation to inulin what happens to the concentration of the following in the tubule: 1. Bicarbonate 2. Glucose 3. Sodium 4. Urea 5. Creatinine

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Inulin is neither reabsorbed nor secreted in the nephron so its clearance accurately measures GFR. 1. Bicarbonate concentration falls in relation to inulin. 90 % of filtered bicarbonate is reabsorbed in the proximal tubule. 2. 100 % of filtered glucose is reabsorbed in the proximal tubule so its relative concentration would drop to 0 in relation to inulin. 3. Sodium is reabsorbed in same proportion as water so its relative concentration would remain about 1 until loop of Henle and DCT where it is reabsorved so relative concentration would decrease. 4. Urea: 50 % filtered urea reabsorved in PCT so relative concentraiton would be less than 3 by end of PT. 5. Creatinine: Creatinine is freely filtered and it is also secreted by the PCT so its concentration would increase in relation to inulin. Creatinine measurements over estimate GFR.
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In relation to inulin what happens to the concentration of the following in the tubule: 1. Bicarbonate 2. Glucose 3. Sodium 4. Urea 5. Creatinine

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In relation to inulin what happens to the concentration of the following in the tubule: 1. Bicarbonate 2. Glucose 3. Sodium 4. Urea 5. Creatinine

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Without work one finishes nothing. - Ralph Waldo Emerson
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