A 14 month old boy comes to GP with persistent itchy rash that has been refractory to topical hydrocortisone cream. Mother says he is often ill with colds/ear infections and he bruises easily. No history of any major illness and he is currently taking oral amoxicillin for a recent ear infection. Exam shows very dry and lightly scaly skin with many excoriations. There are bruises of various stages on arm and shins as well as petechiae. 1. What is likely diagnosis and why? 2. What is elevated in blood serum? 3. Inheritance?

Connective tissue is the most abundant type of tissue in the body. It serves to connect and support other tissues and also has regulatory and immunologic functions. Connective tissue consists of cells, mainly fibroblasts, and an extracellular matrix (ECM).