A 24 yo man with leukemia abruptly develops a rash. He reports a low grade fever, some fatigue, muscle aches and sore throat one week earlier but was not prescribed any medications. Physical exam shows multiple nottender erythematous patches of the distal arms and legs, dorsum of the hands palms and soles of the feet. Some of the patches have pale, vesicular or eroded centers with surrounding erythematous rings. A few small lip and oral lesiosn are noted as well. Biopsy of these lesions reveal apoptotic keratinocytes with lymphocytic infilitrate. Medication reaction has been ruled out. 1. What skin condition does he have? 2. This skin condition has likely been triggered by what virus? Why?

Connective tissue is the most abundant type of tissue in the body. It serves to connect and support other tissues and also has regulatory and immunologic functions. Connective tissue consists of cells, mainly fibroblasts, and an extracellular matrix (ECM).