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Pathophysiology Practice Test: Epigenetics and Disease
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Avg score: 82% • Most missed: “Mutations in the encoding of histone-modifying proteins have been shown to influ…”
Epigenetics is the study of how changes to a gene's DNA can affect an individual without changing the DNA sequence. These changes can contribute to disease.  Some possible causes of epigenetic changes include: Diet, Stressors, and Environmental pollutants.  Epigenetic changes are responsible for human diseases, including: Various cancers Autoimmune disorders Neurological disorders Fragile X syndrome Angelman's syndrome Prader-Willi syndrome  Epigenetic alterations cause chromatin remodeling and altered gene expression. This can lead to inflammation, proliferation, atrophy, and... Show more
Pathophysiology Practice Test: Epigenetics and Disease
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12 Questions

1. During which stage of human development does the role of epigenetics have the greatest impact on the development of epigenetic abnormalities?
2. Mutations in the encoding of histone-modifying proteins have been shown to influence the development of what congenial condition?
3. What is the role of inactive MLH1 in the development of some forms of inherited colon cancer?
4. What comorbid condition does an individual diagnosed with Beckwith-Wiedemann syndrome have an increased risk of developing?
5. Which embryonic stem cell characteristic is referred to as totipotent?
6. When considering abnormal epigenetic modifications, what factor is currently being viewed as strongly associated with the development of some cancers?
7. What characteristic of Prader-Willi syndrome is not a characteristic of Angelman syndrome?
8. Housekeeping genes are vital to the function and maintenance of all the body’s cells. What characteristic is associated with these genes?
9. Screening tools that are epigenetically based have shown promise in diagnosing which types of cancer?
10. Research has demonstrated that neural stem cells have an impaired ability to differentiate into functional neurons when subjected to:
11. 5-Azacytidine has demonstrated promise in the treatment of which form of cancer?
12. Research has provided support for the theory that epigenetic modifications can result from deficient in utero nutrition causing which chronic disease?

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