GPAT Paper 2011
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GPAT Paper 2011
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25 Questions

1. Determine the correctness or otherwise of the following Assertion (A) and the Reason (R): Assertion (A): For a pharmaceutical powder, true density is greater than the granule density. Reason (R): Mercury displacement used for determining granule density, allows penetration of liquid into internal pores of the particles.
2. What will be the time required for a drug exhibiting first order rate constant of 4.6/h to be degraded from initial concentration of 100 mg/ml to 10 mg/ml?
3. Patients taking isosorbide mononitrate or nitroglycerine should be advised not to take sildenafil. This drug-drug interaction causes which of the following actions?
4. Which of the following isothems are produced when the heat of condensation of successive layers is more than the heat of adsorption of first layer?
5. Choose the correct statement for writing the sequence of amino acids in a polypeptide.
6. Given are the four statements about NMB: (P) 13CMR is a less sensitive technique than PMR (Q) Both 13C and: H have 1=1/2 (R) Precessional frequency of the nucleus is directly proportional to the applied magnetic field. (S) Deuterium exchange studies can be performed to ascertain protons attached to heteroatoms. Choose the correct combination of statements.
7. Which of the following is a non-competitive inhibitor of the enzyme reverse transcriptase in HIV?
8. In context of complexometry (complexometric titrations), the two terms labile and inert complexes, are used frequently. Choose the correct statement about them.
9. Which of the following drug does not induce mydriasis?
10. Aprotic polar solvents increase the rate of SN2 reactions manifold. Enhancement in the rate of such reactions is due to which one of the following effects?
11. A drug whose solubility is 1 g/L in water, when given orally at a dose of 500 mg is absorbed upto 95% of the administered dose. The drug belongs to which class according to the BCS classification?
12. Choose the correct pair of the neurodegenerative disorders from those given below.
13. What is the wavenumber equivalent of 400 nm wavelength?
14. Which amongst the following auxochromes produces a shift towards higher energy wavelength?
15. Choose the correct statement about the given four diseases: (P) Cardiomyopathy (Q) Rheumatoid arthritis (R) Myasthenia gravis (S) Ulcerative colitis
16. A drug is administered to a 65 kg patient as 500 mg tablets every 4 hours. Half-life of the drug is 3 h, volume of distribution is 2 litre/kg and oral bioavailability of the drug is 0.85. Calculate the steady state concentration of the drug.
17. Which of the following statements is true for angiotensin- II.
18. Which of the following pairs has high binding affinity for Sa-reductase?
19. Most of the emergency contraceptives have one of the following active ingredients?
20. Alkenes show typical electrophilic addition reactions. I. an electronwithdrawing group is attached to one of the carbons bearing the double bond, what will happen to the mechanism of the addition reaction?
21. Which of the following acts as a non-ionic emulsifying agent?
22. Which statement is not true for steam distillation?
23. P-Glycoprotein pump is responsible for which one of the following?
24. In the electrochemical series, the standard reduction potentials of copper and zinc are + 0.337 V and ' 0.763 V, respectively. If the half cells of both of these metals are connected externally to each other through an external circuit and a salt bridge, which one of the following processes will take place?
25. Two genetic types of Cannabis i.e., drug type and Hemp type are cultivated. (P) Drug type cannabis is rich in (-)A-transtetrahydrocannabinol. (Q) Hemp type cannabis is rich in cannabidiol (R) Drug type cannabis is rich in cannabidiol (S) Hemp type cannabis contains elongated bast fibres Which one of the given statements is correct?

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